'strDDir  要检索的目录，strSearchChr 要检索的文件名

Private Function SetFileRB(ByVal strDDir As String, ByVal strSearchChr As String) As Integer
        Dim dirInfo As New DirectoryInfo(strDDir)
        Dim intCnt As Integer = 1
        Dim intTemp As Integer = 0
        If dirInfo.Exists Then
            Dim files As FileInfo() = dirInfo.GetFiles(strSearchChr)
            Dim i As Integer
            For i = 0 To files.Length - 1

　　　　　　　　'自己的处理
            Next
        End If
        Return intCnt
    End Function

String[] files = Directory.GetFiles("BasePath", "*autoCAD2005\acad.exe");//*匹配路径

然后是对BasePath的递归查找，如果是你全匹配的返回路径。

            System.IO.Directory.GetFiles("BasePath", "acad.exe", SearchOption.AllDirectories);

这样就可以了。