System.Drawing.Bitmap

 int Width = 200;
        int Height = 200;
        System.Drawing.Image image;
        string FilePath = Server.MapPath("UpFile/") + "woody.jpg";
        image = System.Drawing.Bitmap.FromFile(FilePath);
        Bitmap Img = new Bitmap(Width, Height);
        string newFilePath = Server.MapPath("UpFile/") + "newwoody.jpg";
        System.Drawing.Graphics gp = Graphics.FromImage(Img);
        Rectangle rl = new Rectangle(0, 0, 200, 200);
        gp.DrawImage(image, rl);
        Img.Save(newFilePath);
        Img.Dispose();
        gp.Dispose();
        image.Dispose();