你看这里的 Overriding Configuration 里面有所用的各种情况。

public class Program
{
    public static void Main(string[] args)
    {
        BuildWebHost(args).Run();
    }

    public static IWebHost BuildWebHost(string[] args)
    {
        var config = new ConfigurationBuilder()
            .SetBasePath(Directory.GetCurrentDirectory())
            .AddJsonFile("hosting.json", optional: true)
            .AddCommandLine(args)
            .Build();

        return WebHost.CreateDefaultBuilder(args)
            .UseUrls("http://*:5000")
            .UseConfiguration(config)
            .Configure(app =>
            {
                app.Run(context => 
                    context.Response.WriteAsync("Hello, World!"));
            })
            .Build();
    }
}